Accessing Chemically Differentiated 1,5-dienes Through Palladium Catalyzed Allyl-Allyl Cross-Coupling with Internal Allyl Electrophiles

Abstract

Internal allyl electrophiles were successfully implemented in a catalytic cross-coupling to allylB(pin) with high regiocontrol to afford multisubstituted 1,5-dienes bearing chemically differentiated olefins. Construction of alkenyl compounds with all carbon quaternary centers and high enantiomeric excess can be achieved in one step without the use of enantiomerically enriched chiral ligands.