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Miller, Chase Allen. “Towards a Web-Based, Big Data, Genomics Ecosystem”, Boston College, 2014. http://hdl.handle.net/2345/bc-ir:104052.
Abstract
Rapid advances in genome sequencing enable a wide range of biological experiments on a scale that was until recently restricted to large genome centers. However, the analysis of the resulting vast genomic datasets is time-consuming, unintuitive and requires considerable computational expertise and costly infrastructure. Collectively, these factors effectively exclude many bench biologists from genome-scale analyses. Web-based visualization and analysis libraries, frameworks, and applications were developed to empower all biological researchers to easily, interactively, and in a visually driven manner, analyze large biomedical datasets that are essential for their research, without bioinformatics expertise and costly hardware.